Article
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.
Molecular and cellular neurosciences - 1 Nov 2008
Kanninen Katja, Malm Tarja M, Jyrkkänen Henna-Kaisa, Goldsteins Gundars, Keksa-Goldsteine Velta, Tanila Heikki, Yamamoto Masayuki, Ylä-Herttuala Seppo, Levonen Anna-Liisa, Koistinaho Jari
Abstract excerpt
Nuclear factor erythroid 2-related factor 2 (Nrf2) coordinates the up-regulation of cytoprotective genes via the antioxidant response element (ARE). In the pathogenesis of Alzheimer's disease (AD) current evidence supports the role of oxidative stress. Considering the protective role of Nrf2 agai...
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