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Article

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

18 Jul 2016

Abstract excerpt

Autophagy is a highly coordinated process that is controlled at several levels including transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2) as a regulator of autophagy gene expression and its relevance in a mouse model of Alzheimer disease (AD) that reproduces impaired APP (amyloid β precursor protein) and human (Hs)MAPT/TAU processing,...

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PMID: 27427974
DOI: 10.1080/15548627.2016.1208889

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