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Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.

Glia - 1 Jan 2026

Guo Shenrui, Wei Feng, Sun Hui, Jin Hongfu, Cheng Weiwei, Fu Chenglai, Wang Hui, Yin Yafu

Abstract excerpt

Astrocyte reactivity is a common feature of Alzheimer's disease (AD), with reactive astrocytes traditionally subdivided into neurotoxic or neuroprotective phenotypes. It's crucial to transform neurotoxic reactive astrocytes to neuroprotective phenotypes for the treatment of AD, particularly during the progression of the disease. In this study, we evaluated the role of nuclear factor E2-related factor 2 (Nrf2) in...

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PMID: 41017285
DOI: 10.1002/glia.70087

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