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Article

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice

21 Jan 2019

Abstract excerpt

Molecular signaling mechanisms underlying Alzheimer's disease (AD) remain unclear. Maintenance of memory and synaptic plasticity depend on de novo protein synthesis, dysregulation of which is implicated in AD. Recent studies showed AD-associated hyperphosphorylation of mRNA translation factor eukaryotic elongation factor 2 (eEF2), which results in inhibition of protein synthesis. We tested to determine whether...

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PMID: 30667373
DOI: 10.1172/jci122954

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