Article

Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells

2022-01-10

Abstract excerpt

Domestication of transposable elements (TEs) into functional cis-regulatory elements is a widespread phenomenon. However, the mechanisms behind why some TEs are co-opted as functional enhancers while others are not are underappreciated. SINE-VNTR-Alus (SVAs) are the youngest group of transposons in the human genome, where ∼3,700 copies are annotated, nearly half of which are human-specific. Many studies indicate t...

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Literature Corpus work: cc2fa67a-3891-59e1-b6e9-f454ec2763ce
DOI: 10.1101/2022.01.10.475682

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