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Reduced <i>SH3RF3</i> may protect against Alzheimer’s disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

2024-06-28

Abstract excerpt

<h4>Summary</h4> Understanding how high-risk individuals are protected from Alzheimer’s disease (AD) may illuminate potential therapeutic targets. We identified protective genetic variants in SH3RF3 / POSH2 that delayed the onset of AD among individuals carrying the PSEN1 G206A mutation. SH3RF3 acts as a JNK pathway scaffold and activates NFκB signaling. While effects of SH3RF3 knockdown in human neurons wer...

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Literature Corpus work
73cb36f8-90b1-5dfb-9a6e-c8f8047d75ad
DOI
10.1101/2024.06.23.600281
Open publication

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