Article

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

2024-06-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to confer resistance to autosomal dominant Alzheimer’s Disease (AD). However, it remains unclear whether and how this variant exerts its protective effects. <h4>Methods</h4> W...

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Literature Corpus work: 3293c045-ed9f-5df4-9b1f-dc3ea348332c
DOI: 10.1101/2024.06.03.597211

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