Article

FYN, SARS-CoV-2, and IFITM3 in the Neurobiology of Alzheimer’s Disease: A Regulatory Feedback Loop Governing Tau and Aβ Pathology

2020-12-29

Abstract excerpt

<h4>Introduction: </h4> IFITM3, an innate immune protein linked to COVID-19 severity, has recently been identified as a novel γ-secretase modulator. Independent research has shown that IFITM3 may facilitate SARS-CoV-2 neurotropism in an ACE2-independent manner. In a previous study, we had detected perturbations in IFITM3 networks in both the CNS and peripheral immune cells donated by AD patients.The purpose...

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Literature Corpus work: 1e6ae498-3d75-5724-a7e5-ed15fc456649
DOI: 10.20944/preprints202012.0739.v1

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