Article
Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease.
The Journal of biological chemistry - 12 Apr 2013
Surmeier D James, Schumacker Paul T
Abstract excerpt
The most distinguishing feature of neurons is their capacity for regenerative electrical activity. This activity imposes a significant mitochondrial burden, especially in neurons that are autonomously active, have broad action potentials, and exhibit prominent Ca(2+) entry. Many of the genetic mutations and toxins associated with Parkinson's disease compromise mitochondrial function, providing a mechanistic...
Topics
- Animals
- Calcium
- Calcium Channels, L-Type
- Energy Metabolism
- Humans
- Mitochondria
- Mutation
- Neurons
- Parkinson Disease