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Article

Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons.

PloS one - 1 Jan 2014

Sgobio Carmelo, Kupferschmidt David A, Cui Guohong, Sun Lixin, Li Zheng, Cai Huaibin, Lovinger David M

Abstract excerpt

Calcium triggers dopamine release from presynaptic terminals of midbrain dopaminergic (mDA) neurons in the striatum. However, calcium transients within mDA axons and axon terminals are difficult to study and little is known about how they are regulated. Here we use a newly-developed method to measure presynaptic calcium transients (PreCaTs) in axons and terminals of mDA neurons with a genetically encoded calcium...

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Identifiers

PMID: 25360513
DOI: 10.1371/journal.pone.0111749
PMCID: PMC4216119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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