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Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease

19 Apr 2021

Abstract excerpt

Selective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer's disease (AD), however the degree of involvement of the different brain regions differs among patients. We classified corticolimbic patterns of neurofibrillary tangles in postmortem tissue to capture extreme and representative phenotypes. We combined...

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PMID: 33875655
DOI: 10.1038/s41467-021-22399-3

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