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Article

Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis.

Genomics - 1 Jul 2019

Akila Parvathy Dharshini S, Taguchi Y-H, Michael Gromiha M

Abstract excerpt

The selective vulnerability of distinct regions of the brain is a critical factor in neurodegenerative disorders. In Alzheimer's disease (AD), neurons in hippocampus situated in medial temporal lobe are immensely damaged. Identifying tissue-specific variants is essential in order to perceive the selective vulnerability in AD. In current work, we aligned mRNA-seq data with HG19/HG38 genomic assembly and identified...

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PMID: 29879491
DOI: 10.1016/j.ygeno.2018.05.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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