Article

Depletion of tropomyosin 1.6 promotes matrix-degrading phenotype in TGF-β1-induced myofibroblast

2023-12-08

Abstract excerpt

Fibroblasts can be transformed into myofibroblasts under pro-fibrotic conditions, which is characterized by increased contractility and reduced matrix degradation. The relationship between contractile activity and matrix degradation is not fully understood. We found that TGF-β1-induced myofibroblast activation occurs on a culture dish, favoring stress fiber formation and inhibiting podosome structures due to high...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 731c966a-676a-516f-ba28-7d6be11f48df
DOI: 10.1101/2023.12.08.570775

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Depletion of tropomyosin 1.6 promotes matrix-degrading phenotype in TGF-β1-induced myofibroblastDOI 10.1101/2023.12.08.570775Read

TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblastsSemantic proximity Read

Myofibroblast differentiation is governed by adhesion mechanics, and inhibition of Talin2 reverses lung and kidney fibrosisSemantic proximity Read

Distinct extracellular matrix states uncouple collagen accumulation from pathological fibrosis in Duchenne muscular dystrophySemantic proximity Read

Targeting F-actin stress fibers to suppress the dedifferentiated phenotype in chondrocytes.Semantic proximity Read

Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activationSemantic proximity Read

Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activation.Semantic proximity Read

MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype.Semantic proximity Read

MRTF-A signaling regulates the acquisition of the contractile phenotype in dedifferentiated chondrocytes.Semantic proximity Read

Myofibroblast Markers and Microscopy Detection Methods in Cell Culture and Histology.Semantic proximity Read

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.Semantic proximity Read

Featured Article: TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblastsSemantic proximity Read

TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating SMAD2/3 transcription factorsSemantic proximity Read