Article

Distinct extracellular matrix states uncouple collagen accumulation from pathological fibrosis in Duchenne muscular dystrophy

2026-08-17

Abstract excerpt

Fibrosis severity is routinely inferred from collagen abundance, although whether collagen quantity determines pathological fibrosis remains unclear. In Duchenne muscular dystrophy (DMD), chronic muscle injury and inflammation drive extracellular matrix accumulation, making these processes difficult to disentangle. We exploit sarcospan overexpression in mdx mice, a model of DMD ( mdx TG ), which improves membran...

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Literature Corpus work: 25bf10d4-c689-5f38-bfcc-8a1d52103de8
DOI: 10.64898/2026.08.11.739868

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