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Article

MRTF-A signaling regulates the acquisition of the contractile phenotype in dedifferentiated chondrocytes.

Matrix biology : journal of the International Society for Matrix Biology - 1 Oct 2017

Parreno Justin, Raju Sneha, Wu Po-Han, Kandel Rita A

Abstract excerpt

Chondrocyte culture as a monolayer for cell number expansion results in dedifferentiation whereby expanded cells acquire contractile features and increased actin polymerization status. This study determined whether the actin polymerization based signaling pathway, myocardin-related transcription factor-a (MRTF-A) is involved in regulating this contractile phenotype. Serial passaging of chondrocytes in monolayer...

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Identifiers

PMID: 27751947
DOI: 10.1016/j.matbio.2016.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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