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Article

Targeting F-actin stress fibers to suppress the dedifferentiated phenotype in chondrocytes.

European journal of cell biology - 1 Jun 2024

Schofield Mandy M, Rzepski Alissa T, Richardson-Solorzano Stephanie, Hammerstedt Jonah, Shah Sohan, Mirack Chloe E, Herrick Marin, Parreno Justin

Abstract excerpt

Actin is a central mediator of the chondrocyte phenotype. Monolayer expansion of articular chondrocytes on tissue culture polystyrene, for cell-based repair therapies, leads to chondrocyte dedifferentiation. During dedifferentiation, chondrocytes spread and filamentous (F-)actin reorganizes from a cortical to a stress fiber arrangement causing a reduction in cartilage matrix expression and an increase in...

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Identifiers

PMID: 38823166
DOI: 10.1016/j.ejcb.2024.151424
PMCID: PMC11610718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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