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Article

MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype.

Experimental cell research - 1 Aug 2012

Howard Eric W, Crider Beverly J, Updike Dawn L, Bullen Elizabeth C, Parks Eileen E, Haaksma Carol J, Sherry David M, Tomasek James J

Abstract excerpt

During wound healing, fibroblasts transition from quiescence to a migratory state, then to a contractile myofibroblast state associated with wound closure. We found that the myofibroblast phenotype, characterized by the expression of high levels of contractile proteins, suppresses the expression of the pro-migratory gene, MMP-2. Fibroblasts cultured in a 3-D collagen lattice and allowed to develop tension showed...

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Identifiers

PMID: 22449415
DOI: 10.1016/j.yexcr.2012.03.007
PMCID: PMC4164435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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