Article

TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating SMAD2/3 transcription factors

2019-05-30

Abstract excerpt

Fibrosis is associated with almost all forms of chronic cardiac and skeletal muscle diseases. The accumulation of extracellular matrix impairs the contractility of muscle cells contributing to organ failure. Transforming growth factor beta (TGF-β) plays a pivotal role in fibrosis, activating pro-fibrotic gene programs via phosphorylation of SMAD2/3 transcription factors. However, the mechanisms that control de-pho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e323d1c-d912-572f-9aff-e2781f546021
DOI: 10.1101/655332

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating SMAD2/3 transcription factorsDOI 10.1101/655332Read

Targeting TGF-β signaling for the treatment of fibrosisSemantic proximity Read

The TGFβ superfamily in cardiac dysfunctionSemantic proximity Read

Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ ConvergeSemantic proximity Read

The Role of the TGF-β Superfamily in Myocardial InfarctionSemantic proximity Read

Role of TGF-β signaling in inherited and acquired myopathiesSemantic proximity Read

Molecular Interplay in Cardiac Fibrosis: Exploring the Functions of RUNX2, BMP2, and NotchSemantic proximity Read

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosisSemantic proximity Read

Osteopontin aggravates myocardial fibrosis by promoting phenotypic transition of cardiac fibroblasts via Hippo-YAP pathway.Semantic proximity Read

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signalingSemantic proximity Read

YAP/TAZ inhibition refines TGF-β signaling to prevent laryngeal fibrosisSemantic proximity Read

The long-noncoding RNA MALAT1 regulates TGF-β/Smad signaling through formation of a lncRNA-protein complex with Smads, SETD2 and PPM1A in hepatic cellsSemantic proximity Read

PTEN Regulates Myofibroblast Activation in Valvular Interstitial Cells based on Subcellular LocalizationSemantic proximity Read