Article

Myofibroblast differentiation is governed by adhesion mechanics, and inhibition of Talin2 reverses lung and kidney fibrosis

2021-06-07

Abstract excerpt

Fibrosis is involved in 45% of deaths in the United States, and no treatment exists to reverse progression of the disease. In order to find novel targets for fibrosis therapeutics, we developed a model for the differentiation of monocytes to myofibroblasts that allowed us to screen for proteins involved in myofibroblast differentiation. Inhibition of a novel protein target generated by our model, talin2, reduces m...

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Literature Corpus work: 2412ccf7-090f-557d-b2f2-d7e01986f21a
DOI: 10.1101/2021.06.07.447403

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