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Pharmacological and Transcriptomic Exploration of β2-Adrenergic Receptor-Gα15 Signaling in THP-1-Derived Macrophages

2026-02-11

Abstract excerpt

Myocardial infarction and heart failure are leading global causes of mortality. Chronic β-adrenergic receptor (βAR) activation in cardiomyocytes promotes heart failure via Gαs signaling after myocardial infarction, whereas β2AR activation may also provide cardiac protection and repair through alternative pathways. Macrophages play a pivotal role in cardiac repair, and β2AR has been reported to signal via the hemat...

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Literature Corpus work
7307efe4-3813-512f-833c-f19fefe9c48e
DOI
10.64898/2026.02.09.704723
Open publication

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Pharmacological and Transcriptomic Exploration of β2-Adrenergic Receptor-Gα15 Signaling in THP-1-Derived MacrophagesDOI 10.64898/2026.02.09.704723
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