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BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes.

Clinical epigenetics - 11 Nov 2020

Wasiak Sylwia, Dzobo Kim E, Rakai Brooke D, Kaiser Yannick, Versloot Miranda, Bahjat Mahnoush, Stotz Stephanie C, Fu Li, Sweeney Michael, Johansson Jan O, Wong Norman C W, Stroes Erik S G, Kroon Jeffrey, Kulikowski Ewelina

Abstract excerpt

BACKGROUND: Patients with cardiovascular disease (CVD) and type 2 diabetes (DM2) have a high residual risk for experiencing a major adverse cardiac event. Dysregulation of epigenetic mechanisms of gene transcription in innate immune cells contributes to CVD development but is currently not targeted by therapies. Apabetalone (RVX-208) is a small molecule inhibitor of bromodomain and extra-terminal (BET)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33172487
DOI: 10.1186/s13148-020-00943-0
PMCID: PMC7657365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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