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Article

NR4A2 alleviates cardiomyocyte loss and myocardial injury in rats by transcriptionally suppressing CCR5 and inducing M2 polarization of macrophages.

Microvascular research - 1 Mar 2022

Miao Huangtai, Li Xiaoying, Zhou Can, Liang Ying, Li Deshun, Ji Qingwei

Abstract excerpt

BACKGROUND: CC chemokine receptor 5 (CCR5) has been demonstrated to be correlated to activation of pro-inflammatory immune cells and tissue injury. This study focused on the role of CCR5 in myocardial injury in rats with diabetic cardiomyopathy (DCM) and the mechanism of action. METHODS: A rat model of DCM was induced by streptozotocin (STZ). CCR5 was knocked down in rats to determine its role in myocardial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34774582
DOI: 10.1016/j.mvr.2021.104279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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