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Article

Mas receptor activation regulates the functional phenotype of myocardial macrophages through the Akt/Nrf2 signaling pathway to alleviate sepsis-induced cardiomyopathy.

Journal of translational medicine - 24 Apr 2026

Chen Xin-Sen, Shao Meng, Ge Hua-Jun, Jiang Ting, Fan Shuo, Zhou Juan, Li Na, Huang Min, Zhang Lu

Abstract excerpt

BACKGROUND: Sepsis-induced cardiomyopathy (SIC) has high mortality due to uncontrolled cardiac inflammation and macrophage-mediated mitochondrial damage. The Ang-(1–7)/Mas receptor (MasR) axis exhibits anti-inflammatory effects, but its role in modulating macrophage phenotypes in SIC remains unclear. This study aimed to determine if MasR activation confers cardioprotective effects in SIC via the macrophage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myocytes, Cardiac

Share to NF-E2-Related Factor 2

Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 42032737
DOI: 10.1186/s12967-026-08171-5
PMCID: PMC13251021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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