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Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers

26 Jun 2017

Abstract excerpt

Myocyte Enhancer Factor 2 (MEF2) mediates cardiac remodelling in heart failure (HF) and is also a target of β-adrenergic signalling, a front-line treatment for HF. We identified global gene transcription networks involved in HF with and without β-blocker treatment. Experimental HF by transverse aortic constriction (TAC) in a MEF2 "sensor" mouse model (6 weeks) was followed by four weeks of β-blockade with...

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PMID: 28667250
DOI: 10.1038/s41598-017-04762-x

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