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Article

How Carvedilol activates β2-adrenoceptors

19 Nov 2022

Abstract excerpt

Abstract Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond blockade of β1-adrenoceptors, arrestin-biased signalling via β2-adrenoceptors is a molecular mechanism proposed to explain the survival benefits. Here, we offer an alternative mechanism to rationalize...

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Share to Cardiac electrophysiology and arrhythmias
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36402762
DOI: 10.1038/s41467-022-34765-w

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