Article
Myocardin is a master regulator of smooth muscle gene expression.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003
Wang Zhigao, Wang Da-Zhi, Pipes G C Teg, Olson Eric N
Abstract excerpt
Virtually all smooth muscle genes analyzed to date contain two or more essential binding sites for serum response factor (SRF) in their control regions. Because SRF is expressed in a wide range of cell types, it alone cannot account for smooth muscle-specific gene expression. We show that myocardin, a cardiac muscle- and smooth muscle-specific transcriptional coactivator of SRF, can activate smooth muscle gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.