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Article

Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.

Nature - 11 Mar 2004

Wang Zhigao, Wang Da-Zhi, Hockemeyer Dirk, McAnally John, Nordheim Alfred, Olson Eric N

Abstract excerpt

Smooth muscle cells switch between differentiated and proliferative phenotypes in response to extracellular cues, but the transcriptional mechanisms that confer such phenotypic plasticity remain unclear. Serum response factor (SRF) activates genes involved in smooth muscle differentiation and proliferation by recruiting muscle-restricted cofactors, such as the transcriptional coactivator myocardin, and ternary...

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Source

Identifiers

PMID: 15014501
DOI: 10.1038/nature02382

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.PMID 15014501Read ↗

Myocardin is a master regulator of smooth muscle gene expression.Semantic proximity Read ↗

The serum response factor coactivator myocardin is required for vascular smooth muscle development.Semantic proximity Read ↗

Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression.Semantic proximity Read ↗

Myocardin: a component of a molecular switch for smooth muscle differentiation.Semantic proximity Read ↗

Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1.Semantic proximity Read ↗

HERP1 Inhibits Myocardin-Induced Vascular Smooth Muscle Cell Differentiation by Interfering With SRF Binding to CArG BoxSemantic proximity Read ↗

SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodelingSemantic proximity Read ↗

Molecular regulation of vascular smooth muscle cell differentiation in development and disease.Semantic proximity Read ↗

Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin.Semantic proximity Read ↗

The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression.Semantic proximity Read ↗

Megakaryoblastic Leukemia-1/2, a Transcriptional Co-activator of Serum Response Factor, Is Required for Skeletal Myogenic DifferentiationSemantic proximity Read ↗

Myocardin-dependent Activation of the CArG Box-rich Smooth Muscle γ-Actin GeneSemantic proximity Read ↗

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