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The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription

16 Mar 2016

Abstract excerpt

The Werner syndrome (WS) is a prototypic adult Mendelian progeroid syndrome in which signs of premature aging are associated with genomic instability and an elevated risk of cancer. The WRN RECQ helicase protein binds and unwinds G-quadruplex (G4) DNA substrates in vitro, and we identified significant enrichment in G4 sequence motifs at the transcription start site and 5' ends of first introns (false discovery...

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PMID: 26984941
DOI: 10.1093/hmg/ddw079

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