Article

Werner syndrome helicase modulates G4 DNA-dependent transcription and opposes mechanistically distinct senescence-associated gene expression programs

2015-08-04

Abstract excerpt

Werner syndrome (WS) is a prototypic heritable adult human progeroid syndrome in which signs of premature aging are associated with genetic instability and an elevated risk of specific types of cancer. We have quantified mRNA and microRNA (miRNA) expression in WS patient fibroblasts, and in WRN-depleted fibroblasts. Genes down-regulated in WS patient fibroblasts were highly enriched in G-quadruplex (G4) DNA motifs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: adb6828f-696f-5c76-bf4a-e53024b03d3a
DOI: 10.1101/023739

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Werner syndrome helicase modulates G4 DNA-dependent transcription and opposes mechanistically distinct senescence-associated gene expression programsDOI 10.1101/023739Read

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcriptionSemantic proximity Read

Recent Advances in Understanding Werner SyndromeSemantic proximity Read

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responsesSemantic proximity Read

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read

Research on Werner Syndrome: Trends from Past to Present and Future ProspectsSemantic proximity Read

Werner Syndrome, aging and cancer.Semantic proximity Read

The Werner syndrome RECQ helicase as a therapeutic target: new insights.Semantic proximity Read

Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.Semantic proximity Read

WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.Semantic proximity Read

Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions.Semantic proximity Read

WRN mutations in Werner syndrome.Semantic proximity Read

A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).Semantic proximity Read