Article

Quantifying the Acute Toxicity of Alpha-Synuclein Membrane-Accumulation in a Cell-Based Assay

2026-01-21

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects over 12 million people worldwide. A central pathological feature is the accumulation of aggregated alpha-synuclein (αS) in Lewy bodies and Lewy neurites. Engineered αS variants such as 3K (E35K + E46K + E61K) and KLK (KTKEGV→KLKEGV in 6 repeats) have been shown to enhance membrane binding and aggregation p...

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Literature Corpus work: 728bdd0b-335b-5dbf-8577-b16d68f8931e
DOI: 10.21203/rs.3.rs-8576084/v1

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