Article

A Dual Assay to Compare Protein Levels and Toxicity of Alpha-Synuclein Variants: Acute Expression of Wild-Type versus S129A

2025-09-23

Abstract excerpt

Parkinson’s disease (PD) affects over 12 million people worldwide and has the fastest-growing global impact. The pathological hallmark is the presence of Lewy bodies and Lewy neurites, which are intraneuronal lesions enriched in aggregated alpha-synuclein (αS) that is typically hyper-phosphorylated at serine 129. Therefore, lowering phosphoserine 129 (pS129) may be a viable therapeutic strategy to treat PD. Howeve...

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Literature Corpus work: 82f9ac56-0a84-5a47-82aa-c58a17457827
DOI: 10.1101/2025.09.23.678012

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