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Article

Quantifying the Acute Toxicity of Alpha-Synuclein Membrane-Accumulation in a Cell-Based Assay.

Journal of molecular neuroscience : MN - 22 Aug 2026

Li Baoyi, Anderson Amirah K, Alnakhala Heba, Levy Oren A, Ramalingam Nagendran, Dettmer Ulf

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects over 12 million people worldwide. A central pathological feature is the accumulation of aggregated alpha-synuclein (αS) in Lewy bodies and Lewy neurites. Engineered αS variants such as 3K (E35K+E46K+E61K) and KLK (KTKEGV→KLKEGV in 6 repeats) have been shown to enhance membrane binding and aggregation propensity, contributing to...

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Identifiers

PMID: 42631812
DOI: 10.1007/s12031-026-02578-x
PMCID: PMC13499741

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SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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