Article

Alpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM models.

2025-10-08

Abstract excerpt

<title>Abstract</title> <p>Alpha‑synuclein (α‑syn) overexpression models are widely used to unravel the molecular mechanisms of Parkinson’s disease (PD), particularly in light of the dose-dependent transition between its physiological and toxic roles. However, existing systems rely on inducible expression, lack robust dose stratification and comparative cellular contexts. Here, we developed and characterized a pa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 628c4a55-eb30-53ef-9d7d-37e136505dbb
DOI: 10.21203/rs.3.rs-7416994/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM models.DOI 10.21203/rs.3.rs-7416994/v1Read

Alpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM modelsSemantic proximity Read

Cellular models of alpha‐synuclein toxicity and aggregationSemantic proximity Read

Chronic α-Synuclein Over-Expression and Ceruloplasmin Challenge Promote Distinct Iron and Redox Responses in M17 CellsSemantic proximity Read

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neuronsSemantic proximity Read

Quantifying the Acute Toxicity of Alpha-Synuclein Membrane-Accumulation in a Cell-Based AssaySemantic proximity Read

Selective vulnerability in α-synucleinopathiesSemantic proximity Read

Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific PhenotypesSemantic proximity Read

In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategiesSemantic proximity Read

The good and bad of therapeutic strategies that directly target α‐synucleinSemantic proximity Read

Differential roles of proteasome and autophagy in α-synuclein and E46K oligomer clearance: insight into the modulatory effects of the dopamine metabolite DOPAC.Semantic proximity Read

Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model.Semantic proximity Read

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.Semantic proximity Read