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Article

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.

International journal of molecular sciences - 22 Jul 2020

Terry-Kantor Elizabeth, Tripathi Arati, Imberdis Thibaut, LaVoie Zachary M, Ho Gary P H, Selkoe Dennis, Fanning Saranna, Ramalingam Nagendran, Dettmer Ulf

Abstract excerpt

Genetic and biochemical evidence attributes neuronal loss in Parkinson's disease (PD) and related brain diseases to dyshomeostasis of the 14 kDa protein α-synuclein (αS). There is no consensus on how αS exerts toxicity. Explanations range from disturbed vesicle biology to proteotoxicity caused by fibrillar aggregates. To probe these mechanisms further, robust cellular toxicity models are needed, but their...

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PMID: 32707907
DOI: 10.3390/ijms21155193
PMCID: PMC7432784

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