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Article

The alpha-synuclein mutation E46K promotes aggregation in cultured cells.

Experimental neurology - 1 Feb 2006

Pandey Neeraj, Schmidt Robert E, Galvin James E

Abstract excerpt

Parkinson's disease (PD) is characterized by the polymerization of wild-type (WT) or mutant alpha-synuclein (AS) into aggregates and fibrils, which are observed as Lewy bodies (LBs) and Lewy neurites (LNs) in PD patients. However, inability to demonstrate aggregation in many cell culture systems is a major drawback for effective in vitro modeling of AS aggregation. Utilizing PCR-based cloning approach, we...

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PMID: 16325180
DOI: 10.1016/j.expneurol.2005.10.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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