Article

Alpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM models

2025-08-27

Abstract excerpt

Alpha-synuclein (α-syn) overexpression models are widely used to unravel the molecular mechanisms of Parkinson’s disease (PD), particularly in light of the dose-dependent transition between its physiological and toxic roles. However, existing systems rely on inducible expression, lack robust dose stratification and comparative cellular contexts. Here, we developed and characterized a panel of stable neuronal cell...

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Literature Corpus work: 5178bb18-02e0-5212-bb41-ad4fdad48a59
DOI: 10.1101/2025.08.23.671356

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Alpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM modelsDOI 10.1101/2025.08.23.671356Read

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