Article

Mitochondrial pathway polygenic risk scores are associated with Alzheimer’s Disease

2020-11-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Genetic, animal and epidemiological studies involving biomolecular and clinical endophenotypes implicate mitochondrial dysfunction in Alzheimer’s disease (AD) pathogenesis. Polygenic risk scores (PRS) provide a novel approach to assess biological pathway-associated disease risk by combining the effects of variation at multiple, functionally related genes. <h4>METHODS</h4>...

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Literature Corpus work: 7266a134-c539-5e80-a810-6a6994404708
DOI: 10.1101/2020.11.06.371286

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