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Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease.

Neurobiology of aging - 1 Dec 2021

Paliwal Devashi, McInerney Tim W, Pa Judy, Swerdlow Russell H, Easteal Simon, Andrews Shea J

Abstract excerpt

Genetic, animal and epidemiological studies involving biomolecular and clinical endophenotypes implicate mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis. Polygenic risk scores (PRS) provide a novel approach to assess biological pathway-associated disease risk by combining the effects of variation at multiple, functionally related genes. We investigated the associations of PRS for genes involved...

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Identifiers

PMID: 34521561
DOI: 10.1016/j.neurobiolaging.2021.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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