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Mitochondrial and autophagy-lysosomal pathway polygenic risk scores predict Parkinson's disease.

Molecular and cellular neurosciences - 1 Jul 2022

Dehestani Mohammad, Liu Hui, Sreelatha Ashwin Ashok Kumar, Schulte Claudia, Bansal Vikas, Gasser Thomas

Abstract excerpt

Polygenic Risk Scores (PRS), which allow assessing an individuals' genetic risk for a complex disease, are calculated as the weighted number of genetic risk alleles in an individual's genome, with the risk alleles and their weights typically derived from the results of genome-wide association studies (GWAS). Among a wide range of applications, PRS can be used to identify at-risk individuals and select them for...

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PMID: 35710056
DOI: 10.1016/j.mcn.2022.103751

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