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Article

Polygenic Liability to Alzheimer's Disease Is Associated with a Wide Range of Chronic Diseases: A Cohort Study of 312,305 Participants.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Wu Bang-Sheng, Zhang Ya-Ru, Yang Liu, Zhang Wei, Deng Yue-Ting, Chen Shi-Dong, Feng Jian-Feng, Cheng Wei, Yu Jin-Tai

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) patients rank among the highest levels of comorbidities compared to persons with other diseases. However, it is unclear whether the conditions are caused by shared pathophysiology due to the genetic pleiotropy for AD risk genes. OBJECTIVE: To figure out the genetic pleiotropy for AD risk genes in a wide range of diseases. METHODS: We estimated the polygenic risk score (PRS)...

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Identifiers

PMID: 36442194
DOI: 10.3233/JAD-220740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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