Article

Evaluating the causal effect of mitochondrial dysfunction on Alzheimer’s and Parkinson’s disease using Polygenic Risk Scores and Mendelian Randomization

2025-09-27

Abstract excerpt

<h4>INTRODUCTION</h4> Mitochondrial DNA copy number (mtDNAcn), a measure of mitochondrial genomes per nucleated cell, has an unclear causal relationship with AD and PD. We integrate genetic correlation, Polygenic Risk Scores (PRS), and Mendelian Randomization (MR) to assess whether mtDNAcn influences the risk of AD and PD, and evaluate how study-specific factors in mtDNAcn genome-wide association studies (GWAS) m...

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Literature Corpus work: c2746a39-ca90-502f-a365-8b67d1815a8f
DOI: 10.1101/2025.09.25.25336251

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