Article

Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson’s disease

2023-05-16

Abstract excerpt

<h4>Background</h4> Parkinson’s disease (PD) is the fastest growing neurodegenerative disorder, with affected individuals expected to double during the next 20 years. This raises the urgent need to better understand the genetic architecture and downstream cellular alterations underlying PD pathogenesis, in order to identify more focused therapeutic targets. While only ∼10% of PD cases can be clearly attributed to...

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Literature Corpus work: 4051dfe0-e421-57a5-9d40-81ec0da595ac
DOI: 10.1101/2023.05.12.23289877

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