Article

An imbalance of naïve and effector T-cell phenotypes in early type 1 diabetes across conventional and regulatory subsets

2024-12-10

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease caused by the loss of self-tolerance toward insulin-producing pancreatic β-cells. Although the etiology of T1D is not fully understood, it is linked to dysregulation of the T-cell compartment. To identify T-cell signatures associated with T1D, we performed single-cell transcriptomic analysis of peripheral blood T-cells from newly diagnosed children, the same children...

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Literature Corpus work: 9cf4df16-10aa-5d0a-8818-37dd84815ef6
DOI: 10.1101/2024.12.05.627068

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