Article

Activated regulatory T-cells, dysfunctional and senescent T-cells dominate the microenvironment of pancreatic cancer

2020-06-20

Abstract excerpt

Pancreatic cancer has the worst prognosis of any human malignancy and leukocyte infiltration is a major prognostic marker of the disease. As current immunotherapies confer negligible survival benefits, there is a need to better characterise leukocytes in pancreatic cancer to identify better therapeutic strategies. In this study, we analysed 32 human pancreatic cancer patients from two independent cohorts. A multi-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54254266-2f21-589b-a052-fa1a6402fb6a
DOI: 10.1101/2020.06.20.163071

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activated regulatory T-cells, dysfunctional and senescent T-cells dominate the microenvironment of pancreatic cancerDOI 10.1101/2020.06.20.163071Read

Activated Regulatory T-Cells, Dysfunctional and Senescent T-Cells Hinder the Immunity in Pancreatic CancerSemantic proximity Read

An Integrated Multi-Omics Analysis Identifying Immune Subtypes of Pancreatic CancerSemantic proximity Read

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma.Semantic proximity Read

Tumor-specific CD4 T cells cooperate with myeloid cells to remodel the pancreatic tumor microenvironment and enable effective immunotherapySemantic proximity Read

A Multi-Omics Analysis of an Exhausted T Cells’ Molecular Signature in Pan-CancerSemantic proximity Read

Characterization of Exhausted T Cell Signatures in Pan-Cancer SettingsSemantic proximity Read

Novel Insights into T-Cell Exhaustion and Cancer Biomarkers in PDAC Using ScRNA-SeqSemantic proximity Read

Aberrant immune regulation and enrichment of stem-like CD8 <sup>+</sup> T cells in the pancreatic lymph node during type 1 diabetes developmentSemantic proximity Read

Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer.Semantic proximity Read

Tumor-Infiltrating Leukocyte Compositions and Prognostic Immune-Related Genes in Pancreatic Cancer.Semantic proximity Read

Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancerSemantic proximity Read

Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironmentSemantic proximity Read