Article

Beyond the classical plasma secretome: genetic architecture and disease associations of the expanded human plasma proteome in 13,445 Europeans

2026-07-27

Abstract excerpt

Circulating plasma proteins are key biomarkers and therapeutic targets, now measurable at scale through high-throughput technologies, yet whether expanding proteomics platforms beyond the classical plasma secretome enhances genetic discovery and causal inference remains poorly understood. Here, we use an expanded SomaScan 7k platform to map the genetic architecture of a broader segment of the plasma proteome and t...

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Literature Corpus work: 7213c519-06a7-5cd2-a38d-7692c06cb690
DOI: 10.64898/2026.07.23.26358667

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