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Sex differences in the genetic regulation of the human plasma proteome

13 May 2025

Abstract excerpt

Mechanisms underlying sex differences in the development and prognosis of many diseases remain largely elusive. Here, we systematically investigated sex differences in the genetic regulation of plasma proteome (>5800 protein targets) across two cohorts (30,307 females; 26,058 males). Plasma levels of two-thirds of protein targets differ significantly by sex. In contrast, genetic effects on protein targets are...

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PMID: 40360480
DOI: 10.1038/s41467-025-59034-4

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