Article

Ancestry diversity in the genetic determinants of the human plasma proteome enhances identification of potential drug targets

2023-11-13

Abstract excerpt

The proteome is fundamental to human biology and health but little is known about ancestral diversity of its genetic determinants. In GWAS of plasma levels of 2,923 proteins in 3,974 Chinese adults, we identified pQTLs for 1,784 proteins, including 1,312 cis -pQTLs for 1,264 proteins. Fine-mapping identified 3,475 credible sets for independent pQTLs, 36% of which were distinct from those identified in European ad...

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Literature Corpus work: 123053b4-75c4-5f29-8a03-6306c2fa404e
DOI: 10.1101/2023.11.13.23298365

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