Article

Consequences of natural perturbations in the human plasma proteome

2017-05-05

Abstract excerpt

Proteins are the primary functional units of biology and the direct targets of most drugs, yet there is limited knowledge of the genetic factors determining inter-individual variation in protein levels. Here we reveal the genetic architecture of the human plasma proteome, testing 10.6 million DNA variants against levels of 2,994 proteins in 3,301 individuals. We identify 1,927 genetic associations with 1,478 prote...

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Literature Corpus work: 004036da-b3bf-5e3f-88b4-23d44bd505b7
DOI: 10.1101/134551

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