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Article

Involvement of human ORC and TRF2 in pre‐replication complex assembly at telomeres

29 Aug 2008

Abstract excerpt

The origin recognition complex (ORC) binds to replication origins to regulate the cell cycle-dependent assembly of pre-replication complexes (pre-RCs). We have found a novel link between pre-RC assembly regulation and telomere homeostasis in human cells. Biochemical analyses showed that human ORC binds to TRF2, a telomere sequence-binding protein that protects telomeres and functions in telomere length...

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Share to DNA Repair Mechanisms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18761675
DOI: 10.1111/j.1365-2443.2008.01224.x

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