Article

Chromatin activity identifies differential gene regulation across human ancestries

2022-11-25

Abstract excerpt

Current evidence suggests that cis -regulatory elements controlling gene expression may be the predominant target of natural selection in humans and other species. Detecting selection acting on these elements is critical to understanding evolution but remains challenging because we do not know which mutations will affect gene regulation. To address this, we devised an approach to search for lineage-specific selec...

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Literature Corpus work: 71cc63fc-d593-5e34-aec3-a0b4ab16c72c
DOI: 10.1101/2022.11.25.517959

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